Publications of Dr. John P. Richard

1. K. Toth and J. P. Richard, "Covalent Catalysis by Pyridoxal: Evaluation of the Effect of the Cofactor on the Carbon Acidity of Glycine", J. Am. Chem. Soc., 129, 3013-3021 (2007).
2. T. L. Amyes and J. P. Richard, "Enzymatic Catalysis of Proton Transfer at Carbon: Activation of Triosephosphate Isomerase by Phosphite Dianion", [Hot Article] Biochemistry, 46, 5841-5854 (2007).
3. J. P. Richard and K. B. Williams, "A Marcus Treatment of Rate Constants for Protonation of Ring-Substituted α-Methoxystyrenes: Intrinsic Reaction Barrier and the Shape of the Reaction Coordinate", J. Am. Chem. Soc., 129, 6952-6961 (2007).
4. Chi-Tung Chiang, Marek Freindorf, Thomas Furlani, Robert L. DeLeon, John P. Richard and James F. Garvey, "Characterization of a Three Electron Interaction Between Ammonia and the Benzene Radical Cation", J. Phys. Chem., 111, 6068-6076 (2007).
5. Erik R. Farquhar, John P. Richard and Janet R. Morrow, "Formation and Stability of Mononuclear and Dinuclear Eu(III) Complexes and Their Catalytic Reactivity Toward Cleavage of an RNA Analog", Inorg. Chem., 46, 7169-7177 (2007).
6. John P. Richard, Wing-Yin Tsang, "A Simple Method to Determine Kinetic Deuterium Isotope Effects and Evidence that Proton Transfer To Carbon Proceeds Over and not Through the Reaction Barrier", J. Am. Chem. Soc., 129, 10330-10331 (2007).
7. Krisztina Toth, Tina L. Amyes, Kui Chan, Bryant M. Wood, John A. Gerlt and John P. Richard, "Product Deuterium Isotope Effect on OMP Decarboxylase: Evidence for the Existence of a Short-Lived Carbanion Intermediate", J. Am. Chem. Soc., 129, 12946-12947 (2007).
8. Tina L. Amyes and John P. Richard, "Rational Design of Transition State Analogues as Potent Enzyme Inhibitors with Therapeutic Applications", ACS Chemical Biology, 2, 711-714 (2007).
9. Tina L. Amyes, Bryant M. Wood, Kui Chan, John A. Gerlt and John P. Richard, "Formation and Stability of a Vinyl Carbanion at the Active Site of Orotidine 5'-Monophosphate Decarboxylase: pK_a of the C-6 Proton of Enzyme-Bound UMP", J. Am. Chem. Soc., 1574-1575 (2008).
10. Juan Crugeiras, Ana Rios, Enrique Riveiros, Tina L. Amyes, Glycine Enolates: The Effect of Formation of Iminium Ions to Simple Ketones on α-Amino Carbon Acidity and a Comparison with Pyridoxal Iminium Ions", J. Am. Chem. Soc., 2041-2050 (2008).