Publications of Dr. Thomas I. Kalman

1. T. I. Kalman and L. Lai, "6-Substituted 5-Fluorouracil Derivatives as Transition State Analogue Inhibitors of Thymidine Phosphorylase," Nucleosides Nucleotides & Nucleic Acids 2005, 24, 367-374.
2. M. Jackson, S. Chopra, R. D. Smiley, P. O'Neal Maynard, A. Rosowsky, E. R. London, L. Levy, T. I. Kalman and E. E. Howell, "Calorimetric Studies of Ligand Binding in R67 Dihydrofolate Reductase," Biochemistry 2005, 44, 12420-12433.
3. T. I. Kalman, "Rational Design of Nucleotide Analogs as Mechanism-Based Inhibitors of Thymidylate Synthase", in Frontiers in Nucleosides and Nucleic Acids, R. F. Schinazi and D. C. Liotta, Eds., 2004, pp. 401-429.
4. X.-J. Jiang and T.I. Kalman, "Synthesis of 4-Formyl-4-imidazolin-2-one Nucleosides, Isomers of Uridine and 2'-Deoxyuridine," Nucleosides Nucleotides & Nucleic Acids 2004, 23, 307-316.
5. R.L. Saxl, J. Reston, Z. Nie, T.I. Kalman and F. Maley, "Modification of Escherichia coli Thymidylate Synthase at Tyrosine-94 by 5-Imidazolylpropynyl-2'-deoxyuridine 5'-Monophosphate," Biochemistry 2003, 42, 4544-4551.
6. T.I. Kalman, Z. Nie and A. Kamat, "5-Propynylpyrimidine Nucleoside Derivatives: Rationally Designed Mechanism-Based Inactivators of Thymidylate Synthase," Nucleosides Nucleotides & Nucleic Acids 2001, 20, 869-871.
7. T.I. Kalman and Z. Nie, "Rational Design of Selective Antimetabolites of DNA-Thymine Biosynthesis: 5-Propynylpyrimidine Nucleoside Derivatives," Nucleosides Nucleotides 2000, 19, 357-369.
8. T.S. Maurer, J. Pan, B.P. Booth, T.I. Kalman and H.-L. Fung, "Examination of N-Hydroxylation as a Prerequisite Mechanism of Nitric Oxide Synthase Inactivation," Bioorg. Med. Chem. Lett. 2000, 10, 1077-1080.
9. T.I. Kalman, Z. Nie and A. Kamat, "Mechanism-Based Inactivation of Thymidylate Synthase by 5-(3-Fluoropropyn-1-yl)-2’-deoxyuridine 5’-Phosphate," Bioorg. Med. Chem. Lett. 2000, 10, 391-394.
10. T.I. Kalman, K. Sen and X.-J. Jiang, "Mechanism of Inhibition of HIV Reverse Transcriptase by 1-(2’-Deoxy-b-D-ribofuranosyl)-4-acetylimidazolin-2-one (Imidine)," Nucleosides Nucleotides 1999, 18, 847-848.
11. T.I. Kalman, "Mechanistic Similarities between Thymidylate Synthase and IMP Dehydrogenase: A Common Strategy of Catalysis," Nucleosides Nucleotides 1999, 18, 845-846.
12. T.I. Kalman, "A New Look at the Molecular Mechanism of Thymidylate Synthase and Its Interaction with Nucleotide Analogues," Nucleosides Nucleotides 1999, 18, 843-844.
13. P. Ge and T.I. Kalman, "Structural Assignment of 2,3,6,7-Tetrahydro-5H,10H- [1,5,3]dioxazepino[3,2-c]indolo[3,2-g]pteridin-7-one, a New Heterocyclic Ring Sysytem," J. Heterocyclic Chem. 1998, 35, 257-260.
14. P. Ge and T.I. Kalman, "Design and Synthesis of 3,5-Dialkylamino Substituted 8H,10H-3(R),5(R),15b(S)-2,3,6,7-Tetrahydro-1,5,3-dioxazepino[3,2-c]indolo[3,2-g]pteridin-7-ones," Bioorganic Med. Chem. Letters 1997, 7, 3023-3026.
15. T.W. Abraham, T.I. Kalman, E.J. McIntee and C.R. Wagner, "Synthesis and Biological Activity of Aromatic Amino Acid Phosphoramidates of 5-Fluoro-2'-deoxyuridine and 1-b-Arabinofuranosylcytosine: Evidence for Phosphoramidase Activity," J. Med. Chem. 1996, 39, 4569-4575.
16. J.J. McGuire, T. Tsukamoto, B.P. Hart, J.K. Coward, T.I. Kalman and J. Galivan, "Exploitation of Folate and Antifolate Polyglutamylation to Achieve Selective Anticancer Chemotherapy," Investigational New Drugs 1996, 14, 317-323.
17. Z. Mao, J. Pan and T.I. Kalman, "Design and Synthesis of Histidine Analogues of Folic Acid and Methotrexate as Potential Folylpolyglutamate Synthetase Inhibitors," J. Med. Chem. 1996, 39, 4340-4344.
18. P. Ge, G.O. Voronin and T.I. Kalman, "Synthesis and Structure Determination of a Nucleoside-Derived New Heterocyclic System: 8H,10H,15b(S)-2,3,6,7-Tetrahydro-1,5,3-dioxazepino[3,2-c]indolo[3,2-g]pteridine-7-one," Nucleosides Nucleotides 1996, 15, 1701-1710.
19. X.-J. Jiang and T.I. Kalman, "Synthesis of a Novel Antiretroviral Thymidine Analog: 1-(2-Deoxy-b-D-ribofuranosyl)-4-acetylimidazolin-2-one (Imidine)," Nucleosides Nucleotides 1994, 13, 379-388.
20. S.G.Kerr and T.I. Kalman, "N-(Dialkylamino)methylene Derivatives of 2'-Deoxycytidine and Arabinocytidine: Physicochemical Studies for Potential Prodrug Applications," J. Pharm. Sci. 1994, 83, 582-586.
21. S.G. Kerr and T.I. Kalman, "Highly Water-Soluble Lipophilic Prodrugs of the Anti-HIV Nucleoside Analogue 2',3'-Dideoxycytidine and Its 3'-Fluoro Derivative," J. Med. Chem. 1992, 35, 1996-2001.
22. V. Cody, and T.I. Kalman, "Conformational Analysis of Two Anti-HIV Nucleoside Analogues, 2',3'-Dideoxy-3'-Fluorocytidine and Its N4-Dimethylaminomethylene Prodrug Derivative," Nucleosides Nucleotides 1992, 11, 731-738.
23. P.J. Harvison and T.I. Kalman, "Synthesis and Biological Activity of Novel Folic Acid Analogues: Pteroyl S-Alkylhomocysteine Sulfoximines," J. Med. Chem. 1992, 35, 1227-1233.
24. T. Huang, B.J. Barclay, T.I. Kalman, R.C. von Borstel and P.J. Hastings, "The Phenotype of a Dihydrofolate Reductase Mutant of Saccharomyces cerevisiae," Gene 1992, 121, 167-171.
25. V. Cody, J.R. Luft, E. Ciszak, T.I. Kalman and J.H. Freisheim, "Crystal Structure Determination at 2.3A of Recombinant Human Dihydrofolate Reductase Ternary Complex with NADPH and Methotrexate-g-tetrazole," Anticancer Drug Design 1992, 7, 483-491.
26. P.V. Wagh and T.I. Kalman, "A Rapid Colorimetric Assay for g-Glutamyl Hydrolase (Conjugase)," Anal. Biochem. 1992, 207, 1-5.