- Antimicrobial and anti-inflammatory agents
- Combinatorial chemistry
- Drug design and discovery
- Chemosensitisers for multidrug resistance
- B. S., Akron University, 1960
- Ph.D., Harvard University, 1966
Antimicrobial & Anti-inflammatory Agents, Combinatorial Chemistry, Drug Design & Discovery, Chemosensitisers for Multidrug Resistance
Our research activity involves drug discovery in the areas of topical antimicrobial and antiinflammatory agents, as well as, agents for reversing multidrug resistance in cancer and other infectious diseases.
Trifluorosal, a new agent designed and developed in these laboratories, has undergone efficacy studies against gingivitis in a beagle dog model, in collaboration with the Department of Oral Biology. A human clinical study against acne will now be undertaken.
Pfizer Warner-Lambert funded a contract for the preparation of focused chemical libraries for the discovery of new antiseptic agents with potential applications for the control of oral dental plaque and gingivitis. This work has resulted in the establishment of an automated organic synthesis laboratory within the department.
In collaboration with Marilyn Morris, Department of Pharmaceutics, a pilot project seeks to demonstrate the development of a focused combinatorial library of agents designed to inhibit P-glycoprotein while minimizing other systemic pharmacological properties. High throughput screens for measuring P-glycoprotein binding and calcium ion channel blocking potency will be developed to analyze this library.
Selected Recent Publications