Publications of Dr. Richard Cheng

1. Chiu, H.-P.; Cheng, R. P., "Chemoenzymatic Synthesis of (S)-Hexafluoroleucine and (S)-Tetrafluoroleucine," Org. Lett. 2007, in press.
2. Koyack, M. J.; Cheng, R. P., "Biological Applications" in Foldamers: Structures, Properties, and Applications, Hecht, S.; Huc, I., Eds., Wiley-VCH: 2007; pp 229-265.
3. Cheng, R. P.; Girinath, P.; Ahmad, R., "Effect of Lysine Side Chain Length on Intrahelical Glutamate-Lysine Interactions," Biochemistry 2007, 46, 10528.
4. Chiu, H.-P.; Suzuki, Y.; Gullickson, D.; Ahmad, R.; Kokona, B.; Fairman, R.; Cheng, R. P., "Helix Propensity of Highly Fluorinated Amino Acids," J. Am. Chem. Soc. 2006, 128, 15556.
5. Koyack, M. J.; Cheng, R. P., "Design and Synthesis of Biologically Active Beta-peptides," Methods Mol. Biol. 2006, 340, 95.
6. Cheng, R. P., "Beyond De novo Protein Design - De novo Design of Non-natural Folded Oligomers," Curr. Opin. Struct. Biol. 2004 , 14 , 512.
7. Cheng, R. P.; Walsh, S. T. R.; Wright, W. W.; Alonso, D. O. V.; Daggett, V.; Vanderkooi, J. M.; DeGrado, W. F., "The Hydration of Amides in Helices; A Comprehensive Picture from Molecular Dynamics, IR, and NMR," Protein Sci. 2003 , 12 , 520.
8. Cheng, R. P.; DeGrado, W. F., "Long Range Interactions Stabilize the Fold of a Non-natural Oligomer," J. Am. Chem. Soc. 2002 , 124 , 11564.
9. Cheng, R. P.; Suich, D. J.; Cheng, H.; Roder, H.; DeGrado, W. F., "Template-Constrained Somatostatin Analogues; A Biphenyl Linker Induces a Type V‚ Turn," J. Am. Chem. Soc. 2001 , 123 , 12710.
10. Cheng, R. P.; Gellman, S. H.; DeGrado, W. F., "Beta-peptides; From Structure to Function," Chem. Rev. 2001 , 101 , 3219.
11. Cheng, R. P.; DeGrado, W. F., "De novo Design of a Monomeric Helical beta-Peptide Stabilized by Electrostatic Interactions," J. Am. Chem. Soc. 2001 , 123 , 5162.
12. Mezo, A. R.; Cheng, R. P.; Imperiali, B., "Oligomerization of Uniquely Folded Mini-Protein Motifs: Development of Homotrimeric beta-beta-alpha Peptide," J. Am. Chem. Soc. 2001 , 123 , 3885.
13. Cheng, R. P.; Fisher, S. L.; Imperiali, B., "Metallopeptide Design: Tuning the Metal Cation Affinities with Unnatural Amino Acids and Peptide Secondary Structure," J. Am. Chem. Soc. 1996 , 118 , 11349.
14. Struthers, M. D.; Cheng, R. P.; Imperiali, B., "Economy in Protein Design: Evolution of a Metal-Independent beta-beta-alpha Motif Based on the Zinc Finger Domains," J. Am. Chem. Soc. 1996 , 118 , 3073.
15. Struthers, M. D.; Cheng, R. P.; Imperiali, B., "Design of a Monomeric 23-Residue Polypeptide with Defined Tertiary Structure," Science 1996 , 271 , 342.