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Graduate Chemistry Course Offerings

Graduate Chemistry Course Syllabi

Chemistry 501 - Organic Chemistry for Graduate Students This core organic chemistry course introduces reaction mechanisms and organic synthesis to students with varying undergraduate backgrounds in chemistry. Critical skills toward solving mechanism are developed as the underlying organic principles (kinetics, strain, stereoelectronics, stereochemistry and conformational analysis) are elaborted. These principles will be used to predict and understand reactivity and stereochemistry in more sophisticated reactions. Some of the common carbon-carbon bond forming reactions and functional group manipulations are discussed. This common draws on many synthetic examples from the chemical literature to illustrate mechanism, synthetic utility and to exercise predictive skills. Prerequisite: Chemistry 502 - Synthetic Organic Chemistry The aim of this course is to cultivate knowledge of modern organic synthesis. The application of organic reactions to the synthesis of complex molecules, including natural products, will be studied. In addition to synthetic strategies, detailed reaction mechanism, reaction scope and issues in catalysis will be discussed. Prerequisite: Chemistry 503 - Inorganic Chemistry This course is intended to provide students with a broad background in inorganic chemistry. The fundamental concepts of coordination chemistry will be developed, including the structure, bonding, electronic properties, and reactivity of transition metal complexes. The descriptive chemistry of transition metals, lanthanides, and actinides will be covered. The course will conclude with introductions to bioinorganic chemistry, organometallic chemistry, and solid state inorganic chemistry. Prerequisite: Chemistry 504 - Physical Methods in Inorganic Chemistry This course will survey modern physical methods of characterization and study of inorganic and organometallic compounds. Topics include NMR, IR and UV/visible spectroscopy, ESR, and mass spectrometry. Examples of applications of these methods in the current literature will be presented. Prerequisite: Chemistry 505 - Physical Chemistry for Graduate Students This course will begin with a review of the fundamentals of classical thermodynamics with emphasis on the connections between thermodynamics and microscopic structure. The subject matter will then be developed from a molecular and statistical point of view. The usefullness of thermodymanics and associated statistical methods in understanding molecular events in chemical reactions will be stressed. The kinetics of chemical processes will be treated for reactions in both gaseous and condensed phases in the last third with an emphasis on current reaction dynamics (theory and experiment). Prerequisite: Chemistry 506 - Physical Chemistry for Graduate Students II This course will give hands on experience in the use of quantum chemistry software in the calculation of the spectroscopic and structural properties of molecules. After an introduction covering the basic principles of Quantum Mechanics which is needed for the understanding of molecular calculations in chemistry, each student will be assigned an account for the actual calculations. Interpretation of the results will be discussed in detail. Both organic and inorganic examples will be treated. Students are going to have a working knowledge to perform quantum mechanical calculation in support of their research after completion of the course. Course offered in the spring semester. Chemistry 507 - Analytical Chemistry for Graduate Students This course will be a survey comprising two topics: (1) electroanalytical chemistry, including potentiometry, voltammetry, coulometry and coulometric titrations. (2) spectroscopy, including atomic absorption spectroscopy, atomic emission spectroscopy, molecular absorption spectroscopy, and various analytical aspects of non-optical spectroscopy as time permits.

An introduction to relevant instrumentation on these two topics will be discussed.

Prerequisite: Chemistry 508 - Statistics & Instrumentation This course is divided into two topics of analytical chemistry - analytical sensors (2/3) and analytical separations (1/3). Analytical Sensors: This portion will cover a variety of technologies that have been applied to the construction of analytical sensors. They include thermal mass electrochemical, and optic sensors. Chemical techniques used to provide selectivity will also be discussed. Current literature will be used as references.

Analytical Separations: This topic will cover fundamentals of separation sciences, emphasizing chromatographic theory and instrumentation. General concepts in chemical separations will be reviewed, followed by the presentation of commonly used techniques (e.g. GC, HPLC). The course will introduce the students to recent advancements in analytical separations. Specifically, we will discuss capillary separation techniques (i.e., capillary electrophoresis, open tubular liquid chromatography and electrochematography) employed in the analysis of minute sample quantities. Reference material will be taken from the current literature.

Prerequisite: Chemistry 512A - Special Topics in Physical Chemistry: Biophotonics This course will focus on the discussions of the multidisciplinary approach to use of light and photonic materials in the biological systems. The topics included are: (i) Current imaging technology in biological systems using multiphoton fluorophors and upconverting phosphors, (ii) optical coherence tomography, nearfield scanning optical microscopy and scanning force microscopy of biological tissues, cells and molecules, (iii) lasers technology in the medical sciences, and (iv) nanotechnology in biological imaging, diagnostics and therapies in medicine and chemistry. Prerequisite: Chemistry 512B - Special Topics in Physical Chemistry: Numerical Computational Chemistry This is a one credit mini-course which will introduce the student to Mathematica and its use in chemistry. It will consist of five three hour sessions in s computer lab room, to be scheduled one session per week. The time and place will be determined. Emphasis will be placed on using Mathematica for algebraic manipulations, numerical solution methods and graphics. Students will complete a project for their grade. Prerequisite: Chemistry 514A - Special Topics in Organic Chemistry: Bio-Organic Chemistry This course will present some of the recent developments in bioorganic chemistry on various topics such as protein structure and design, nucleic acid strucccture and design, peptide nucleic acids, peptoids, betapeptides, non-natural oligomers, ribozymes, and catalytic antibodies. Basic understanding of the biorelevant molecules will be provided as a foundation, followed by a discussion of recent papers focusing on the structure, function, and design aspects. Prerequisite: Chemistry 514B - Special Topics in Organic Chemistry: Structural Identification This is a spectroscopic course targeted for structural characterization in organic chemistry. Prerequisite: Chemistry 514C - Special Topics in Organic Chemistry: Organometallics in organic Synthesis This course will survey the recent advances of organometallic reactions in modern organic synthesis. Prerequisite: Chemistry 523A - Bioinorganic Chemistry This course will cover current topics of interest in bioinorganic chemistry. Topics to be covered include metalloenzymes and biomimetic inorganic complexes, mettallodrugs and metal ion complexes used as imaging agents in medicine. Prerequisite: Chemistry 530 - Analytical Mass Spectroscopy This course covers modern analytical mass spectrometry techniques and their application to solving research problems. Part of the course will focus on instrumentation-- mass analyzers, ionization sources, detectors, inlet systems, etc. The analytical advantages of each method will be explored, as will an understanding of the fundamental principles, which underlie each methodology. In addition we will examine sophisticated experimental methods, such as tandem mass spectrometry (MS/MS0 for structural elucidation, on-line separations mass spectrometry (GC/MS, LC/MS, CE/MS, etc.) In which the mass spectrometer serves as a detector for separations techniques, and quantification. Another portion of the course will be dedicated to mass spectral interpretation. Topics such as isotope distribution and fragmentation patterns (for organic compounds as well as biological compounds) as useful tools in mass spectral interpretation will be covered. Throughout the course, the broad-ranging applications for mass spectrometry will be underscored, from forensics to geological/archaeological dating to biomolecule sequencing to studying atmospheric chemistry.

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